The Memory, Error and Learning (MEL) group - Publications

Selected Publications

Differential brain mechanisms of selection and maintenance of information during working memory

Working memory is our ability to select and temporarily hold information as needed for complex cognitive operations. the temporal dynamics of sustained and transient neural activity supporting the selection and holding of memory content is not known. to address this problem, we recorded magnetoencephalography (meg) in healthy participants performing a retro-cue working memory task in which the selection rule and the memory content varied independently. multivariate decoding and source analyses showed that selecting the memory content relies on prefrontal and parieto-occipital persistent oscillatory neural activity. by contrast, the memory content was reactivated in a distributed occipito-temporal posterior network, preceding the working memory decision and in a different format that during the visual encoding. these results identify a neural signature of content selection and characterize differentiated spatiotemporal constraints for subprocesses of working memory.significance statementour brain selects and maintains information during short time windows in a way that is essential to reasoning and learning. recent advances in multivariate analysis of brain activity allowed the characterization of brain regions that stores the memory content, but the spatiotemporal neural dynamics underlying working memory sub-processes, namely encoding, selection and maintenance, are not known. we applied multivariate analysis to time-resolved brain signal to characterize the spatiotemporal signature underlying these sub-processes. selection of information relies on sustained oscillatory activity in a network that includes the ventrolateral prefrontal cortex while memory content is transiently replayed in an occipito-temporal network that differs from encoding. our results characterized differentiated spatiotemporal activity underlying encoding, selection and maintenance of information during working memory.

Statistical learning occurs during practice while high-order rule learning during rest period

Knowing when the brain learns is crucial for both the comprehension of memory formation and consolidation and for developing new training and neurorehabilitation strategies in healthy and patient populations. recently, a rapid form of offline learning developing during short rest periods has been shown to account for most of procedural learning, leading to the hypothesis that the brain mainly learns during rest between practice periods. nonetheless, procedural learning has several subcomponents not disentangled in previous studies investigating learning dynamics, such as acquiring the statistical regularities of the task, or else the high-order rules that regulate its organization. here we analyzed 506 behavioral sessions of implicit visuomotor deterministic and probabilistic sequence learning tasks, allowing the distinction between general skill learning, statistical learning, and high-order rule learning. our results show that the temporal dynamics of apparently simultaneous learning processes differ. while high-order rule learning is acquired offline, statistical learning is evidenced online. these findings open new avenues on the short-scale temporal dynamics of learning and memory consolidation and reveal a fundamental distinction between statistical and high-order rule learning, the former benefiting from online evidence accumulation and the latter requiring short rest periods for rapid consolidation.

Consolidation of human skill linked to waking hippocampo-neocortical replay
Cell Reports (2021)

The introduction of rest intervals interspersed with practice strengthens wakeful consolidation of skill. the mechanisms by which the brain binds discrete action representations into consolidated, highly temporally resolved skill sequences during waking rest are not known. to address this question, we recorded magnetoencephalography (meg) during acquisition and rapid consolidation of a sequential motor skill. we report the presence of prominent, fast waking neural replay during the same rest periods in which rapid consolidation occurs. the observed replay is temporally compressed by approximately 20-fold relative to the acquired skill, is selective for the trained sequence, and predicts the magnitude of skill consolidation. replay representations extend beyond the hippocampus and entorhinal cortex to the contralateral sensorimotor cortex. these results document the presence of robust hippocampo-neocortical replay supporting rapid wakeful consolidation of skill., , substantial jumps in performance immediately following short rest periods account for early motor skill learning. in this study, buch et al. report waking hippocampo-neocortical replay during these rest periods that is temporally compressed by 20-fold relative to behavior, selective for the trained skill, and predicts the magnitude of rapid consolidation of skill.

Full List

Voluntary motor commands are preferentially released during restricted sensorimotor beta rhythm phases
Hussain Sara J., Vollmer Mary K., Iturrate Iñaki, Quentin Romain
Biorxiv (2021)
Consolidation of human skill linked to waking hippocampo-neocortical replay
Buch Ethan R., Claudino Leonardo, Quentin Romain, Bönstrup Marlene, Cohen Leonardo G.
Cell Reports (2021)
Statistical learning occurs during practice while high-order rule learning during rest period
Quentin Romain, Fanuel Lison, Kiss Mariann, Vernet Marine, Vékony Teodóra, Janacsek Karolina, Cohen Leonardo G., Nemeth Dezso
Basal ganglia activation localized in meg using a reward task
Sepe-forrest Linnea, Carver Frederick W., Quentin Romain, Holroyd Tom, Nugent Allison C.
From visual awareness to consciousness without sensory input: the role of spontaneous brain activity
Vernet Marine, Quentin Romain, Japee Shruti, Ungerleider Leslie G.
The longer the better? general skill but not probabilistic learning improves with the duration of short rest periods
Fanuel Lison, Plèche Claire, Vékony Teodóra, Quentin Romain, Janacsek Karolina, Nemeth Dezso
Biorxiv (2020)
Differential brain mechanisms of selection and maintenance of information during working memory
Quentin Romain, King Jean-rémi, Sallard Etienne, Fishman Nathan, Thompson Ryan, Buch Ethan, Cohen Leonardo G.
Entrainment of local synchrony reveals a causal role for high-beta right frontal oscillations in human visual consciousness
Vernet Marine, Stengel Chloé, Quentin Romain, Amengual Julià L., Valero-cabré Antoni
mne-bids: organizing electrophysiological data into the bids format and facilitating their analysis
Appelhoff Stefan, Sanderson Matthew, Brooks Teon L., Vliet Marijn Van, Quentin Romain, Holdgraf Chris, Chaumon Maximilien, Mikulan Ezequiel, Tavabi Kambiz, Höchenberger Richard, Welke Dominik, Brunner Clemens, Rockhill Alexander P., Larson Eric, Gramfort Alexandre, Jas Mainak
Reversing working memory decline in the elderly
Quentin Romain, Cohen Leonardo G.
Cortico-thalamic disconnection in a patient with supernumerary phantom limb
Bourlon Clémence, Urbanski Marika, Quentin Romain, Duret Christophe, Bardinet Eric, Bartolomeo Paolo, Bourgeois Alexia
Visual contrast sensitivity improvement by right frontal high-beta activity is mediated by contrast gain mechanisms and influenced by fronto-parietal white matter microstructure
Quentin Romain, Elkin Frankston Seth, Vernet Marine, Toba Monica N., Bartolomeo Paolo, Chanes Lorena, Valero-cabré Antoni
Cerebral Cortex (2016)
Fronto-parietal anatomical connections influence the modulation of conscious visual perception by high-beta frontal oscillatory activity
Quentin Romain, Chanes Lorena, Vernet Marine, Valero-cabré Antoni
Cerebral Cortex (2015)
Frontal eye field, where art thou? anatomy, function, and non-invasive manipulation of frontal regions involved in eye movements and associated cognitive operations
Vernet Marine, Quentin Romain, Chanes Lorena, Mitsumasu Andres, Valero-cabré Antoni
Fronto-tectal white matter connectivity mediates facilitatory effects of non-invasive neurostimulation on visual detection
Quentin Romain, Chanes Lorena, Migliaccio Raffaella, Valabrègue Romain, Valero-cabré Antoni
Neuroimage (2013)
Author response. oscillation and synchrony entrainment: a new breadth for focal non-invasive neurostimulation in the cognitive neurosciences
Valero-cabré Antoni, Quentin Romain, Vernet Marine, Chanes Lorena
The Journal Of Neuroscience: The Official Journal Of The Society For Neuroscience (2013)
Manipulation of pre-target activity on the right frontal eye field enhances conscious visual perception in humans
Chanes Lorena, Chica Ana B, Quentin Romain, Valero-cabré Antoni
Plos One (2012)